Latent Space Approaches to Subtyping in Oncology Trials

Speaker: 
Michael Kane, Yale University
Event time: 
Tuesday, December 4, 2018 - 4:00pm
Location: 
LOM 215 See map
Event description: 

Abstract: New, more effective cancer therapies have upended traditional randomized controlled trials. For targeted therapies and immunotherapies, single-arm trials made up heterogeneous groups of patients have become common. This change has motivated the development of new techniques for identifying patient subtypes based individual-level features. In this talk, we will present a framework based on a latent-space construction to characterize patients by their subtype, increase the predictive response rate, and construct counterfactuals to distinguish the effect of a drug from that of the subtype. Applications based on real trials will be included to illustrate these points. This is joint work with Brian Hobbs at the Cleveland Clinic.

Event Type: 
Applied Mathematics